Scientific Name: Paguma larvata
Taxonomy: Cellular organisms-> Eukaryota-> Opisthokonta-> Metazoa-> Eumetazoa-> Bilateria-> Deuterostomia-> Chordata-> Craniata-> Vertebrata-> Gnathostomata-> Teleostomi-> Euteleostomi-> Sarcopterygii-> Dipnotetrapodomorpha-> Tetrapoda-> Amniota-> Mammalia-> Theria-> Eutheria-> Boreoeutheria-> Laurasiatheria-> Carnivora-> Feliformia
Summary: This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011] [NCBI] [Proteinatlas]
Data set information
| Project | Date | Technology | Tissue | Condition | Cell | PMID/DOI |
|---|---|---|---|---|---|---|
| Vthunter_0007 | 2021.04 | 10X Genomics | Frontal | Normal | 6593 | Link |
| Vthunter_0008 | 2021.04 | 10X Genomics | Kidney | Normal | 1930 | Link |
| Vthunter_0009 | 2021.04 | 10X Genomics | Liver | Normal | 34029 | Link |
| Vthunter_0010 | 2021.04 | 10X Genomics | Lung | Normal | 12863 | Link |
| Vthunter_0011 | 2021.04 | 10X Genomics | Spleen | Normal | 9682 | Link |
Featureplot of receptors
Expression: Broad expression in appendix (RPKM 16.6), lymph node (RPKM 11.0) and 16 other tissues?
